Meiotic spindle assembly and chromosome segregation in oocytes
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چکیده
منابع مشابه
Meiotic spindle assembly and chromosome segregation in oocytes
611 The Rockefeller University Press $30.00 J. Cell Biol. Vol. 215 No. 5 611–619 https://doi.org/10.1083/jcb.201607062 Introduction Sexual reproduction relies on the fusion of paternal and maternal haploid gametes—the sperm and the extremely large oocyte, respectively—forming a new diploid organism. Meiotic divisions contribute solely to the formation of haploid gametes. They consist of two suc...
متن کاملMeiotic spindle assembly and chromosome segregation in oocytes
Oocytes accumulate maternal stores (proteins, mRNAs, metabolites, etc.) during their growth in the ovary to support development after fertilization. To preserve this cytoplasmic maternal inheritance, they accomplish the difficult task of partitioning their cytoplasm unequally while dividing their chromosomes equally. Added to this complexity, most oocytes, for reasons still speculative, lack th...
متن کاملHuman oocytes. Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytes.
Aneuploidy in human eggs is the leading cause of pregnancy loss and several genetic disorders such as Down syndrome. Most aneuploidy results from chromosome segregation errors during the meiotic divisions of an oocyte, the egg's progenitor cell. The basis for particularly error-prone chromosome segregation in human oocytes is not known. We analyzed meiosis in more than 100 live human oocytes an...
متن کاملSpindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes.
Oocytes segregate chromosomes in the absence of centrosomes. In this situation, the chromosomes direct spindle assembly. It is still unclear in this system which factors are required for homologous chromosome bi-orientation and spindle assembly. The Drosophila kinesin-6 protein Subito, although nonessential for mitotic spindle assembly, is required to organize a bipolar meiotic spindle and chro...
متن کاملNEDD1 is crucial for meiotic spindle stability and accurate chromosome segregation in mammalian oocytes.
Defects in meiotic spindle structure contribute to chromosome segregation errors leading to genomic instability in oocytes and embryos upon fertilization. In this study, we analyzed the mechanisms that control spindle microtubule nucleation and stability in mammalian oocytes, and identified NEDD1/GCP-WD as a key regulator. NEDD1 specifically co-localizes with gamma-tubulin and pericentrin at mi...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2016
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201607062